NOVEL BENZOFURAN POTASSIUM CHANNEL BLOCKERS AND USES THEREOF
Disclosed is a substituted benzofuran compound of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are 5-Acetyl-4, 7 -dimethoxy-6-(3-(phenyl)propoxy)benzofuran; 5-Acetyl-4, 7 -dimethoxy-6-( 4-(phenoxy)butoxyl)benzofuran and 5-Acetyl-6-(3-...
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| creator | PAUL, DHARAM CHAPLIN, JASON, HUGH BAELL, JONATHAN, B MOULD, JORGEN, ALVAR FLYNN, BERNARD, LUKE HARVEY, ANDREW, J |
| description | Disclosed is a substituted benzofuran compound of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are 5-Acetyl-4, 7 -dimethoxy-6-(3-(phenyl)propoxy)benzofuran; 5-Acetyl-4, 7 -dimethoxy-6-( 4-(phenoxy)butoxyl)benzofuran and 5-Acetyl-6-(3-phenylpropoxy)benzofuran. Also disclosed is a pharmaceutical composition comprising a compound of formula (I), the use of a compound of formula (I) in the manufacture of a medicament for treating or prevention of autoimmune or chronic inflammatory diseases, or the prevention of rejection of foreign organ transplants and/or related afflictions and a method of intentionally modulating potassium ion channel activity of T-cells ex-vivo by the application of a compound of formula (I) or a pharmaceutically acceptable salt thereof, to said T -cells. |
| format | Patent |
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Examples of compounds of formula (I) are 5-Acetyl-4, 7 -dimethoxy-6-(3-(phenyl)propoxy)benzofuran; 5-Acetyl-4, 7 -dimethoxy-6-( 4-(phenoxy)butoxyl)benzofuran and 5-Acetyl-6-(3-phenylpropoxy)benzofuran. Also disclosed is a pharmaceutical composition comprising a compound of formula (I), the use of a compound of formula (I) in the manufacture of a medicament for treating or prevention of autoimmune or chronic inflammatory diseases, or the prevention of rejection of foreign organ transplants and/or related afflictions and a method of intentionally modulating potassium ion channel activity of T-cells ex-vivo by the application of a compound of formula (I) or a pharmaceutically acceptable salt thereof, to said T -cells.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120427&DB=EPODOC&CC=NZ&NR=575685A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120427&DB=EPODOC&CC=NZ&NR=575685A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PAUL, DHARAM</creatorcontrib><creatorcontrib>CHAPLIN, JASON, HUGH</creatorcontrib><creatorcontrib>BAELL, JONATHAN, B</creatorcontrib><creatorcontrib>MOULD, JORGEN, ALVAR</creatorcontrib><creatorcontrib>FLYNN, BERNARD, LUKE</creatorcontrib><creatorcontrib>HARVEY, ANDREW, J</creatorcontrib><title>NOVEL BENZOFURAN POTASSIUM CHANNEL BLOCKERS AND USES THEREOF</title><description>Disclosed is a substituted benzofuran compound of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are 5-Acetyl-4, 7 -dimethoxy-6-(3-(phenyl)propoxy)benzofuran; 5-Acetyl-4, 7 -dimethoxy-6-( 4-(phenoxy)butoxyl)benzofuran and 5-Acetyl-6-(3-phenylpropoxy)benzofuran. Also disclosed is a pharmaceutical composition comprising a compound of formula (I), the use of a compound of formula (I) in the manufacture of a medicament for treating or prevention of autoimmune or chronic inflammatory diseases, or the prevention of rejection of foreign organ transplants and/or related afflictions and a method of intentionally modulating potassium ion channel activity of T-cells ex-vivo by the application of a compound of formula (I) or a pharmaceutically acceptable salt thereof, to said T -cells.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDx8w9z9VFwcvWL8ncLDXL0UwjwD3EMDvYM9VVw9nD08wNJ-vg7e7sGBSs4-rkohAa7BiuEeLgGufq78TCwpiXmFKfyQmluBjk31xBnD93Ugvz41OKCxOTUvNSSeL8oU3NTMwtTR2OCCgA1MSjE</recordid><startdate>20120427</startdate><enddate>20120427</enddate><creator>PAUL, DHARAM</creator><creator>CHAPLIN, JASON, HUGH</creator><creator>BAELL, JONATHAN, B</creator><creator>MOULD, JORGEN, ALVAR</creator><creator>FLYNN, BERNARD, LUKE</creator><creator>HARVEY, ANDREW, J</creator><scope>EVB</scope></search><sort><creationdate>20120427</creationdate><title>NOVEL BENZOFURAN POTASSIUM CHANNEL BLOCKERS AND USES THEREOF</title><author>PAUL, DHARAM ; CHAPLIN, JASON, HUGH ; BAELL, JONATHAN, B ; MOULD, JORGEN, ALVAR ; FLYNN, BERNARD, LUKE ; HARVEY, ANDREW, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NZ575685A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2012</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PAUL, DHARAM</creatorcontrib><creatorcontrib>CHAPLIN, JASON, HUGH</creatorcontrib><creatorcontrib>BAELL, JONATHAN, B</creatorcontrib><creatorcontrib>MOULD, JORGEN, ALVAR</creatorcontrib><creatorcontrib>FLYNN, BERNARD, LUKE</creatorcontrib><creatorcontrib>HARVEY, ANDREW, J</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PAUL, DHARAM</au><au>CHAPLIN, JASON, HUGH</au><au>BAELL, JONATHAN, B</au><au>MOULD, JORGEN, ALVAR</au><au>FLYNN, BERNARD, LUKE</au><au>HARVEY, ANDREW, J</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NOVEL BENZOFURAN POTASSIUM CHANNEL BLOCKERS AND USES THEREOF</title><date>2012-04-27</date><risdate>2012</risdate><abstract>Disclosed is a substituted benzofuran compound of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are 5-Acetyl-4, 7 -dimethoxy-6-(3-(phenyl)propoxy)benzofuran; 5-Acetyl-4, 7 -dimethoxy-6-( 4-(phenoxy)butoxyl)benzofuran and 5-Acetyl-6-(3-phenylpropoxy)benzofuran. Also disclosed is a pharmaceutical composition comprising a compound of formula (I), the use of a compound of formula (I) in the manufacture of a medicament for treating or prevention of autoimmune or chronic inflammatory diseases, or the prevention of rejection of foreign organ transplants and/or related afflictions and a method of intentionally modulating potassium ion channel activity of T-cells ex-vivo by the application of a compound of formula (I) or a pharmaceutically acceptable salt thereof, to said T -cells.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NOVEL BENZOFURAN POTASSIUM CHANNEL BLOCKERS AND USES THEREOF |
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