NOVEL BENZOFURAN POTASSIUM CHANNEL BLOCKERS AND USES THEREOF

Disclosed is a substituted benzofuran compound of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are 5-Acetyl-4, 7 -dimethoxy-6-(3-(phenyl)propoxy)benzofuran; 5-Acetyl-4, 7 -dimethoxy-6-( 4-(phenoxy)butoxyl)benzofuran and 5-Acetyl-6-(3-...

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Bibliographische Detailangaben
Hauptverfasser:	PAUL, DHARAM, CHAPLIN, JASON, HUGH, BAELL, JONATHAN, B, MOULD, JORGEN, ALVAR, FLYNN, BERNARD, LUKE, HARVEY, ANDREW, J
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed is a substituted benzofuran compound of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are 5-Acetyl-4, 7 -dimethoxy-6-(3-(phenyl)propoxy)benzofuran; 5-Acetyl-4, 7 -dimethoxy-6-( 4-(phenoxy)butoxyl)benzofuran and 5-Acetyl-6-(3-phenylpropoxy)benzofuran. Also disclosed is a pharmaceutical composition comprising a compound of formula (I), the use of a compound of formula (I) in the manufacture of a medicament for treating or prevention of autoimmune or chronic inflammatory diseases, or the prevention of rejection of foreign organ transplants and/or related afflictions and a method of intentionally modulating potassium ion channel activity of T-cells ex-vivo by the application of a compound of formula (I) or a pharmaceutically acceptable salt thereof, to said T -cells.