MEDICINAL DELIVERY SYSTEM AND RELATED METHODS COMPRISING A NICOTINE COATED ON A SALIVA-SOLUBLE POWDER SUCH AS SORBITOL

Disclosed is a method of making a medicinal delivery system for oral delivery of a nicotine compound which satiates nicotine craving for an individual in need of nicotine-craving relief, comprising: providing a paste comprising a solvent-treated nicotine compound that has been at least partially dissolved in a solvent of a bulk sweetener solution to make the nicotine compound more readily dissolvable during ingestion or mastication to promote a high initial nicotine release rate; coating a saliva-soluble bulk sweetener powder with the paste to establish a coated powder premix; and subsequent to establishing the coated powder premix, substantially homogenously distributing the coated powder premix in an edible carrier base selected from the group consisting of a chewing gum base and a lozenge base and combining the edible carrier base and the coated powder premix with a buffer to establish a medicinal delivery system.