Modified IL-4 mutein receptor antagonists

Modified IL-4 mutein receptor antagonists

Disclosed is a purified polynucleotide encoding a modified IL-4 mutein receptor antagonist comprising: (a) a nucleotide sequence as set forth in SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 7, or SEQ ID NO: 8; or (b) a nucleotide sequence encoding a polypeptide having an amino acid sequence as set forth i...

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Bibliographische Detailangaben
Hauptverfasser: ROCZNIAK, STEVE, YUNG, STEPHANIE L, WONG, TERESA MO-FUN, PAN, CLARK, GREVE, JEFFREY MICHAEL, TOMKINSON, ADRIAN, LONGPHRE, MALINDA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed is a purified polynucleotide encoding a modified IL-4 mutein receptor antagonist comprising: (a) a nucleotide sequence as set forth in SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 7, or SEQ ID NO: 8; or (b) a nucleotide sequence encoding a polypeptide having an amino acid sequence as set forth in SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 15, or SEQ ID NO: Also disclosed are corresponding expression vectors, non-human host cells comprising the vector and methods of making the antagonist by culturing the host cell and purifying the protein. Further disclosed is the use of the antagonist for the preparation of a pharmaceutical for treating a human having asthma or related pulmonary conditions. (62) Divided Out of 546151