PYRAZOLEALKANAMIDE SUBSTITUTED THIOPHENES AS AMPA POTENTIATORS

PYRAZOLEALKANAMIDE SUBSTITUTED THIOPHENES AS AMPA POTENTIATORS

Disclosed are pyrazolealkanamide substituted thiophenes represented by general formula (I), or pharmaceutically acceptable salts thereof, wherein the other substituents are disclosed within the specification. Also disclose is the use of the above mentioned compounds for the manufacture of a medicame...

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Bibliographische Detailangaben
Hauptverfasser: MOIR, ELIZABETH MARGARET, RANKOVIC, ZORAN, GILLEN, KEVIN JAMES, JAMIESON, CRAIG, MACLEAN, JOHN, KINNAIRD, FERGUSON
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed are pyrazolealkanamide substituted thiophenes represented by general formula (I), or pharmaceutically acceptable salts thereof, wherein the other substituents are disclosed within the specification. Also disclose is the use of the above mentioned compounds for the manufacture of a medicament for the treatment or prevention of neurodegenerative disorders, cognitive or memory dysfunction, memory and learning disorders, attention disorder, trauma, stroke, epilepsy, Alzheimer's disease, depression, schizophrenia, psychotic disorders, anxiety, autism, a disorder or disease resulting from neurotic agents, substance abuse, alcohol psychiatric disorders, Parkinson's Disease, sleep disorders or narcolepsy or other conditions resulting from sleep deprivation.