2-0'-METHYLADEN0SINE DERIVATIVES AND THEIR USE AS AGONISTS OR ANTAGONISTS OF AN ADENOSINE RECEPTOR

Disclosed is a compound selected from (2R,3R,4R,5R)-5-[6-amino-2-(cyclopentylmethoxy)-9H-purin-9-yl]-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol, (2R,3R,4R,5R)-5-{ 6-amino-2-[(2,2,3,3-tetrafluorocyclobutyl)oxy]-9H-purin-9-yl} -2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol, (2R,3R,4 R,5R)-5-[6-...

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Bibliographische Detailangaben
1. Verfasser:	SAVORY, EDWARD DANIEL
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed is a compound selected from (2R,3R,4R,5R)-5-[6-amino-2-(cyclopentylmethoxy)-9H-purin-9-yl]-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol, (2R,3R,4R,5R)-5-{ 6-amino-2-[(2,2,3,3-tetrafluorocyclobutyl)oxy]-9H-purin-9-yl} -2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol, (2R,3R,4 R,5R)-5-[6-amino-2-(2,5-difluorophenoxy)-9H-purin-9-yl]-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol, (2R,3R,4R,5R)-5-[6-amino-2-(3,4-difluorophenoxy)-9H-purin-9-yl]-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol; (2R,3R,4R,5R)-5-[6-amino-2-[4-chloro-3-(trifluoromethyl)phenoxy]-9H-purin-9-yl]-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol,(2R,3R,4R,5R)-5-(6-amino-2-{ [(1S)-1-methylpropyI]amino} -9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol; and (2R,3R,4R,5R)-5-[6-amino-2-(cyclohexylamino)-9H-purin-9-yl]-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol for treating pain and inflammation.