Antagonists of the vanilloid receptor subtype 1 (VR1) and uses thereof

Antagonists of the vanilloid receptor subtype 1 (VR1) and uses thereof

The disclosure relates to spiro-chroman compounds of formula (I), wherein the variables X1, X2, Y, R1a, R1, R2a, R2b, A1, A2, A3, and A4 are as defined in the specification. These compounds have vanilloid receptor subtype I (VR1) inhibiting activity and are suitable for use in treating pain, neuropa...

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Bibliographische Detailangaben
Hauptverfasser: GOMTSYAN, ARTHUR R, KOENIG, JOHN R, BROWN, BRIAN S, LEE, CHIH-HUNG
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The disclosure relates to spiro-chroman compounds of formula (I), wherein the variables X1, X2, Y, R1a, R1, R2a, R2b, A1, A2, A3, and A4 are as defined in the specification. These compounds have vanilloid receptor subtype I (VR1) inhibiting activity and are suitable for use in treating pain, neuropathic pain, allodynia, pain associated with inflammation or an inflammatory disease, inflammatory hyperalgesia, bladder overactivity, and urinary incontinence.