Multicyclic amino acid derivatives and methods of their use

Multicyclic amino acid derivatives and methods of their use

Disclosed are compounds of formulae I and II, wherein the substituents are as defined in the specification, as well as compositions comprising them. The compounds inhibit TPH1, the isoform of tryptophan hydroxylase which is expressed in the periphery, primarily in the gastrointestinal (GI) tract, an...

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Bibliographische Detailangaben
Hauptverfasser: WU, WENXUE, SHI, ZHI-CAI, WANG, YING, ZHANG, CHENGMIN, LIU, QINGYUN, DEVASAGAYARAJ, AROKIASAMY, ZHANG, HAIMING, SAMALA, LAKSHAMA, MARINELLI, BRENT, TUNOORI, ASHOK, JIN, HAIHONG
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed are compounds of formulae I and II, wherein the substituents are as defined in the specification, as well as compositions comprising them. The compounds inhibit TPH1, the isoform of tryptophan hydroxylase which is expressed in the periphery, primarily in the gastrointestinal (GI) tract, and are therefore useful to treat, prevent and manage serotonin-mediated diseases and disorders.