Carbazole derivatives as pSTAT3/IL-6 inhibitors (carvedilol)

Disclosed is a carbazole derivative of formula (I), or a tautomer, stereoisomer, polymorph, hydrate, solvate, or pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification. Also disclosed is the use of the compound for lowering plasma concentrations of IL-...

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Hauptverfasser: RAO, SIRIPRAGADA MAHENDER, NIRMALA, RAJAGOPALAN, RANI, SHIKHA, RAMACHANDRAN, UMA, MANIKANDAN, LAKSHMANAN, SRINIVAS, AKELLA SATYA SURYA VISWESWARA, SIVASUDAR, VELAIAH, RAJAGOPAL, SRIRAM, SHARADA, DUDDU SAVARAIAH, REDDY, GADDAM OM, BALAJI, RAMACHANDRAN
Format: Patent
Sprache:eng
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Zusammenfassung:Disclosed is a carbazole derivative of formula (I), or a tautomer, stereoisomer, polymorph, hydrate, solvate, or pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification. Also disclosed is the use of the compound for lowering plasma concentrations of IL-6, and for treating inflammatory diseases or immunological diseases, including cancer.