Duocarmycin drug conjugates

Duocarmycin drug conjugates

A compound comprising a derivative of duocarmycin conjugated to a dipeptide linker through a para-amino benzamide (PAB) spacer moiety. The PAB spacer moiety is located between the bicyclic indole of the duocarmycin derivative and the linker. The compound can be used for the treatment of cancer or tu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PAN, CHIN, CHEN, LIANG, KING, DAVID JOHN, GUERLAVAIS, VINCENT, BOYD, SHARON ELAINE, HORGAN, KILIAN, HUANG, HAICHUN, SUFI, BILAL, CARDARELLI, JOSEPHINE M, GANWAR, SANJEEV
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A compound comprising a derivative of duocarmycin conjugated to a dipeptide linker through a para-amino benzamide (PAB) spacer moiety. The PAB spacer moiety is located between the bicyclic indole of the duocarmycin derivative and the linker. The compound can be used for the treatment of cancer or tumor.