Duocarmycin drug conjugates

A compound comprising a derivative of duocarmycin conjugated to a dipeptide linker through a para-amino benzamide (PAB) spacer moiety. The PAB spacer moiety is located between the bicyclic indole of the duocarmycin derivative and the linker. The compound can be used for the treatment of cancer or tu...

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Bibliographische Detailangaben
Hauptverfasser: PAN, CHIN, CHEN, LIANG, KING, DAVID JOHN, GUERLAVAIS, VINCENT, BOYD, SHARON ELAINE, HORGAN, KILIAN, HUANG, HAICHUN, SUFI, BILAL, CARDARELLI, JOSEPHINE M, GANWAR, SANJEEV
Format: Patent
Sprache:eng
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Zusammenfassung:A compound comprising a derivative of duocarmycin conjugated to a dipeptide linker through a para-amino benzamide (PAB) spacer moiety. The PAB spacer moiety is located between the bicyclic indole of the duocarmycin derivative and the linker. The compound can be used for the treatment of cancer or tumor.