Anti-alphavbeta6 antibodies

Disclosed is a monoclonal antibody that is an alpha v beta6 blocking antibody or an antigen binding fragment thereof that (a) specifically binds to alpha v beta6 and not other alpha v integrins or non specific integrins; (b) inhibits the binding of alpha v beta6 to latency associated peptide (LAP) w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	WEINREB, PAUL H, VIOLETTE, SHEILA M, LEONE, DIANE R, SHEPPARD, DEAN, SIMON, KENNETH J
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Disclosed is a monoclonal antibody that is an alpha v beta6 blocking antibody or an antigen binding fragment thereof that (a) specifically binds to alpha v beta6 and not other alpha v integrins or non specific integrins; (b) inhibits the binding of alpha v beta6 to latency associated peptide (LAP) with an IC50 value lower than that of antibody 10D5 and (c) binds alpha v beta6 in either cation independent manner or a cation dependent manner that does not distinguish between the use of Ca2+/Mg2+ and Mn2+ for cation-dependent binding to soluble alpha v beta6, wherein the antibody is not produced by hybridoma 6.3G9 (ATCC accession number PTA-3649) or by hybridoma 6.8G6 (ATCC accession number PTA-3645). Also disclosed are cells producing said antibodies and uses thereof.