P-cadherin antibodies

Provided is an isolated antibody or antigen-binding portion thereof that binds to P-cadherin and comprises a VH domain and a VL domain, wherein the VH domain comprises: a) a VH CDR1, b) a VH CDR2, and c) a VH CDR3, and wherein the VL domain comprises: d) a VL CDR1, e) a VL CDR2 and f) a VL CDR3, all...

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Bibliographische Detailangaben
Hauptverfasser:	BOURNER, MAUREEN JERI, HEAD, RICHARD DAVID, MINTER, RALPH RAYMOND, BAUER, CHRISTOPHER TODD, JOY, WILLIAM DEAN, BOYLE, MELANIE, MOFFAT, MARK ALLEN, GRIGGS, DAVID WILLIAM, MAZZARELLA, RICHARD ALLEN, THIELE, BARRETT RICHARD, VANARSDALE, TODD LEE, CASPERSON, GERALD FRIES
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Provided is an isolated antibody or antigen-binding portion thereof that binds to P-cadherin and comprises a VH domain and a VL domain, wherein the VH domain comprises: a) a VH CDR1, b) a VH CDR2, and c) a VH CDR3, and wherein the VL domain comprises: d) a VL CDR1, e) a VL CDR2 and f) a VL CDR3, all with specified sequences or variants differing only by 1 or 2 conservative amino acid substitutions. Further provided are corresponding nucleic acid molecules encoding said antibodies, with specified sequences.