Proteins binding to cross-beta structure comprising amyloid and methods for detection and modulation of the cross-beta structure, its formation and its associated toxicity

Disclosed is the use of a compound capable of binding to a crossbeta structure for the preparation of a medicament for diminishing unfolded proteins having adopted a partially structured conformation, involved in a conformational disease, wherein said compound is an antibody or comprises a finger do...

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Bibliographische Detailangaben
Hauptverfasser:	KROON, LOUISE MARIA JOHANNA, KRANENBURG, ONNO WOUTER, GEBBINK, MARTIN FRANS BEN GERARD, BOUMA, BAREND
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed is the use of a compound capable of binding to a crossbeta structure for the preparation of a medicament for diminishing unfolded proteins having adopted a partially structured conformation, involved in a conformational disease, wherein said compound is an antibody or comprises a finger domain, wherein said finger domain is derived from fibronectin, FXll or HGFa, and wherein said disease is a disease characterized by amyloid, atherosclerosis, diabetes, bleeding, thrombosis, cancer, sepsis, Multiple Sclerosis, auto-immune diseases, rheumatoid arthritis, disease associated with loss of memory or Parkinson's disease and/or epilepsy.