Chemically defined stabiliser composition comprising at least one amino acid, at least one sugar and at least one polyamine

Disclosed is a vaccine stabiliser composition when used in freeze drying a biological molecule or a micro-organism, said stabiliser composition comprising at least one amino acid, at least one sugar, and at least one polyamine wherein all compounds are chemically defined, thus being free of serum, free of protein, free of animal compounds, free of polymer of which only an average molecular weight or average length of the side chains is known and free of proteinaceous lysate, extract hydrolysate or peptide mixture, wherein the polyamine is at least one selected from the group consisting of ethylene-diamine, cadaverine, putrescine, spermidine and spermine, wherein no compound has a molecular weight or size of a molecular ion that exceeds 203 Da.