Vaccine composition comprising mixtures of multivalent meningococcal outer membrane vesicles

Provided is a multivalent meningococcal bleb composition comprising an immunoprotective amount of a bleb preparation deficient in PorA in that it has less than 80% of the amount of PorA as compared to the same quantity of blebs made from strain H44/76, and an immunoprotective amount of a bleb prepar...

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Bibliographische Detailangaben
Hauptverfasser:	DOMINGUEZ ALVAREZ, FRANCISCO JESUS, POOLMAN, JAN, DESMONS, PIERRE MICHEL, BARBERA MORALES, RAMON FAUSTINO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided is a multivalent meningococcal bleb composition comprising an immunoprotective amount of a bleb preparation deficient in PorA in that it has less than 80% of the amount of PorA as compared to the same quantity of blebs made from strain H44/76, and an immunoprotective amount of a bleb preparation that is not deficient in PorA compared to blebs made from strain H44/76. Also provided are the corresponding vaccine, methods of manufacturing the composition and methods of manufacturing a medicament for the prevention or treatment of meningococcal disease. (62) Divided Out of 537578