Process for preparing lansoprazole by oxidation in the presence of vanadium(V) oxytrifluoride, vanadium(V) triesters and mixtures thereof

Disclosed is a process for preparing lansoprazole represented by formula (I), which comprises oxidising the corresponding thio-ether precursor with an oxidizing agent in the presence of a vanadium catalyst selected from the group consisting of vanadium(V) oxytrifluoride, vanadium(V) triesters (such...

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Hauptverfasser:	SEGULA ZAKELJ, MOJCA, VRECER, FRANC, KOTAR-JORDAN, BERTA, RITLOP, GREGOR
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed is a process for preparing lansoprazole represented by formula (I), which comprises oxidising the corresponding thio-ether precursor with an oxidizing agent in the presence of a vanadium catalyst selected from the group consisting of vanadium(V) oxytrifluoride, vanadium(V) triesters (such as vanadium(V) oxytriethoxide, vanadium(V) oxytripropoxide or vanadium(V) oxytriisopropoxide) and mixtures thereof, and optionally recovering the lansoprazole.