Fused bicyclic carboxamide derivatives for use as cxcr2 inhibitors in the treatment of inflammation

Fused bicyclic carboxamide derivatives for use as cxcr2 inhibitors in the treatment of inflammation

The disclosure relates to compounds of the formula (I) in which R1, R2, X, A, B, D and Y1 to Y4 have the meanings indicated in the specification, and/or a pharmaceutically acceptable salt and/or an ester prodrug or amide prodrug of a carboxylic acid group thereof. Because of their properties as inhi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: GRUENEBERG, SVEN, SHIMSHOCK, STEPHEN, LI, HUI, WEICHSEL, ALEKSANDRA, KNIEPS, STEPHANIE, KOSLEY, RAYMOND W, LANTER, CAROLINA, CZECHTIZKY, WERNGARD, HEITSCH, HOLGER, DEDIO, JUERGEN, SHER, ROSY
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The disclosure relates to compounds of the formula (I) in which R1, R2, X, A, B, D and Y1 to Y4 have the meanings indicated in the specification, and/or a pharmaceutically acceptable salt and/or an ester prodrug or amide prodrug of a carboxylic acid group thereof. Because of their properties as inhibitors of chemokine receptors, especially as CXCR2 inhibitors, the compounds of the formula (I) and the pharmaceutically acceptable salts and prodrugs thereof are suitable for the prevention and treatment of chemokine mediated diseases such as inflammatory diseases.