Potentiators of glutamate receptors

Provided are 3-{[4-(4-Acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenyl]-(S)-hydroxymethyl}-benzoic acid and related compounds which are useful in the treatment of migraine. The compounds are potentiators of mGlu2 receptor and antagonists of the CysLT1 receptor and provide a means to treat disorders a...

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Bibliographische Detailangaben
Hauptverfasser:	GROENDYKE, TODD MICHAEL, KNOBELSDORF, JAMES ALLEN, SCHKERYANTZ, JEFFREY MICHAEL, CORTEZ, GUILLERMO S, KHILEVICH, ALBERT, AICHER, THOMAS DANIEL, MARMSATER, FREDRIK PEHR, TANG, TONY PISAL, MAGNUS, NICHOLAS ANDREW
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are 3-{[4-(4-Acetyl-3-hydroxy-2-propyl-phenoxymethyl)-phenyl]-(S)-hydroxymethyl}-benzoic acid and related compounds which are useful in the treatment of migraine. The compounds are potentiators of mGlu2 receptor and antagonists of the CysLT1 receptor and provide a means to treat disorders associated with glutamate or leukotrienes.