Disubstituted pyrazolobenzodiazepines useful as inhibitors for CDK2 and angiogenesis, and for the treatment of breast, colon, lung and prostate cancer

Disclosed are 7,8-disubstituted pyrazolo[3,4-b][1,4]benzodiazepines of formula IV or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein. Also disclosed is the use of a compound of formula IV as defined above or a pharmaceutically acceptable salt thereof for th...

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Hauptverfasser:	LIU, JIN-JUN, REN, YI, PIZZOLATO, GIACOMO, ZHANG, ZHUMING, THAKKAR, KSHITIJ CHHABILBHAI, WOVKULICH, PETER MICHAEL, LUK, KINUN
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Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	LIU, JIN-JUN REN, YI PIZZOLATO, GIACOMO ZHANG, ZHUMING THAKKAR, KSHITIJ CHHABILBHAI WOVKULICH, PETER MICHAEL LUK, KINUN
description	Disclosed are 7,8-disubstituted pyrazolo[3,4-b][1,4]benzodiazepines of formula IV or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein. Also disclosed is the use of a compound of formula IV as defined above or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of cancer, particular breast cancer, prostate cancer, colon cancer and lung cancer. Additionally disclosed are processes for the preparation of the compounds of formula IV, and pharmaceutical compositions which comprise a compound as defined above together with pharmaceutically acceptable adjuvants. .
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	Disubstituted pyrazolobenzodiazepines useful as inhibitors for CDK2 and angiogenesis, and for the treatment of breast, colon, lung and prostate cancer
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