Metabolic detoxification system and method

Disclosed is an extracorporeal filtration and detoxification system and method generally comprising: (a) separating ultrafiltrate fluid from cellular components of blood that has been drawn from a patient; (b) treating said ultrafiltrate independently of said cellular components in a recirculation circuit, wherein said treating comprises circulating said ultrafiltrate through an active cartridge comprising active cells operative to effectuate a selected treatment of said ultrafiltrate, wherein said active cells have been selected on the basis of the nature of the contaminant to be removed or treated from the ultrafiltrate; and (c) recombining treated ultrafiltrate and said cellular components wherein the composition of said ultrafiltrate is analysed by a device subsequent to said separating.