Diphenyl ox-indol-2-one compounds and their use in the treatment of cancer

Disclosed are substituted 3,3-diphenyl-1,3-dihydro-indol-2-one compounds, wherein at least one of R1-R4 is not H, and the remaining substituents are as defined in the specification. It is postulated that the compounds inhibit protein synthesis and/or inhibit activation of the mTOR pathway, and are u...

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Hauptverfasser:	BUTCHER, STEVEN PETER, REIGNIER, SERGE, KROG-JENSEN, CHRISTIAN, COULTER, THOMAS STEPHEN, PEDERSEN, HANS CHRISTIAN, PRAESTEGAARD, MORTEN, LINDE, VIGGO, MONTALBETTI, CHRISTIAN, UDDIN, MOHAMMED, FELDING, JAKOB
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are substituted 3,3-diphenyl-1,3-dihydro-indol-2-one compounds, wherein at least one of R1-R4 is not H, and the remaining substituents are as defined in the specification. It is postulated that the compounds inhibit protein synthesis and/or inhibit activation of the mTOR pathway, and are useful for the treatment of cancer.