Tubulin inhibitors

Tubulin inhibitors

Disclosed are compounds represented by Fomula (I), (II), (III) and (V), or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof wherein the substituents are listed in the specification. These compounds can be used in the manufacture of a medicament...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WILKS, ANDREW FREDERICK, BURNS, CHRISTOPHER JOHN, HARTE, MICHAEL FRANCIS, FANTINO, EMMANUELLE, SIKANYIKA, HARRISON, SIMS, COLETTE GLORIA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed are compounds represented by Fomula (I), (II), (III) and (V), or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof wherein the substituents are listed in the specification. These compounds can be used in the manufacture of a medicament for modulating microtubule polymerisation and in the treatment of associated disease states.