Triaza-spiro compounds as nociceptin analogues and uses thereof

Triaza-spiro compounds as nociceptin analogues and uses thereof

Disclosed are nociceptin analogues represented by the formula II, wherein the substituents are as defined in the specification. The compounds antagonize the nociceptin (ORL1) receptor and are useful in modulating diuresis and aquaresis, and in the treatment of edema, modulating arterial blood pressu...

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Bibliographische Detailangaben
Hauptverfasser: THORKILDSEN, CHRISTIAN, HANSEN, LARS BO LAURENBORG, LARSEN, BJARNE DUE, KNUDSEN, CARSTEN BOYE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Disclosed are nociceptin analogues represented by the formula II, wherein the substituents are as defined in the specification. The compounds antagonize the nociceptin (ORL1) receptor and are useful in modulating diuresis and aquaresis, and in the treatment of edema, modulating arterial blood pressure, sedating a mammal or reducing nociception in a mammal.