Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof

Disclosed is a compound of Formula (I) wherein R4 is selected from the group consisting of (CF3)n alkyl, (CF3)n(substitutedalkyl), (CF3)nalkylphenyl, (CF3)nalkyl(substitutedphenyl), and (F)ncycloalkyl; and the rest of the substituents are disclosed within the specification. Also disclosed is the use...

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Hauptverfasser: DIAMANTIDIS, GEORGE, RESNICK, LYNN, ZHANG, MINSHENG, GALANTE, ROCCO JOHN, WANG, TINGZHONG, MAYER, SCOTT CHRISTIAN, HOKE, MOLLY, KREFT, ANTHONY FRANK, COLE, DEREK CECIL, HARRISON, BOYD LYNN
Format: Patent
Sprache:eng
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Zusammenfassung:Disclosed is a compound of Formula (I) wherein R4 is selected from the group consisting of (CF3)n alkyl, (CF3)n(substitutedalkyl), (CF3)nalkylphenyl, (CF3)nalkyl(substitutedphenyl), and (F)ncycloalkyl; and the rest of the substituents are disclosed within the specification. Also disclosed is the use of the above compound in the preparation of a medicament for inhibiting beta amyloid production in a subject.