Process for the production of tibolone

Process for the production of tibolone

Disclosed is a process for the production of 17beta-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-ene-20-yne-3-one (tibolone) of the formula (11). The process comprises the step of reacting a compound of formula (6) with copper(II) bromide in the presence of an alcohol R2-OH; wherein the substitu...

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Hauptverfasser: GREENWOOD, ALAN KENNETH, BHATARAH, PARVEEN, MCHATTIE, DEREK
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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creator GREENWOOD, ALAN KENNETH
BHATARAH, PARVEEN
MCHATTIE, DEREK
description Disclosed is a process for the production of 17beta-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-ene-20-yne-3-one (tibolone) of the formula (11). The process comprises the step of reacting a compound of formula (6) with copper(II) bromide in the presence of an alcohol R2-OH; wherein the substituents R and R2 are as defined in the specification, to form a product mixture comprising a compound of formula (7); and optionally contacting the product mixture with a base.
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The process comprises the step of reacting a compound of formula (6) with copper(II) bromide in the presence of an alcohol R2-OH; wherein the substituents R and R2 are as defined in the specification, to form a product mixture comprising a compound of formula (7); and optionally contacting the product mixture with a base.</description><edition>7</edition><language>eng</language><subject>CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; STEROIDS</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20080731&amp;DB=EPODOC&amp;CC=NZ&amp;NR=542298A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20080731&amp;DB=EPODOC&amp;CC=NZ&amp;NR=542298A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GREENWOOD, ALAN KENNETH</creatorcontrib><creatorcontrib>BHATARAH, PARVEEN</creatorcontrib><creatorcontrib>MCHATTIE, DEREK</creatorcontrib><title>Process for the production of tibolone</title><description>Disclosed is a process for the production of 17beta-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-ene-20-yne-3-one (tibolone) of the formula (11). 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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
title Process for the production of tibolone
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