Biaryl substituted triazoles as sodium channel blockers
Disclosed are compounds of formulae (I) - (III), wherein the substituents are as defined in the specification, and a process for their preparation. The compounds are useful for providing local anaesthesia or treating conditions associated with or caused by sodium channel activity, including acute pa...
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| creator | FRANTZ, DOUGLAS E PARK, MIN K FISHER, MICHAEL H PALUCKI, BRENDA KRESS, MICHAEL H ZHOU, BISHAN CHAKRAVARTY, PRASUN K PARSONS, WILLIAM H CAREY, JAMES P WEAVER, DAMIAN |
| description | Disclosed are compounds of formulae (I) - (III), wherein the substituents are as defined in the specification, and a process for their preparation. The compounds are useful for providing local anaesthesia or treating conditions associated with or caused by sodium channel activity, including acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder. |
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The compounds are useful for providing local anaesthesia or treating conditions associated with or caused by sodium channel activity, including acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Biaryl substituted triazoles as sodium channel blockers |
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