Biaryl substituted triazoles as sodium channel blockers

Disclosed are compounds of formulae (I) - (III), wherein the substituents are as defined in the specification, and a process for their preparation. The compounds are useful for providing local anaesthesia or treating conditions associated with or caused by sodium channel activity, including acute pa...

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Bibliographische Detailangaben
Hauptverfasser:	FRANTZ, DOUGLAS E, PARK, MIN K, FISHER, MICHAEL H, PALUCKI, BRENDA, KRESS, MICHAEL H, ZHOU, BISHAN, CHAKRAVARTY, PRASUN K, PARSONS, WILLIAM H, CAREY, JAMES P, WEAVER, DAMIAN
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds of formulae (I) - (III), wherein the substituents are as defined in the specification, and a process for their preparation. The compounds are useful for providing local anaesthesia or treating conditions associated with or caused by sodium channel activity, including acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder.