Pyrimidin-4-one derivatives and their use as p38 kinase modulators

Pyrimidin-4-one derivatives and their use as p38 kinase modulators

Disclosed is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein L and M are independently selected from -O-, -CH2-, -S-, -N(R)-N(R)-, -C(=O)- and -SO2-, and the remaining substituents are as defined in the specification. The compounds are useful for treating diseases ca...

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Bibliographische Detailangaben
Hauptverfasser: MADSEN, HEATHER, HICKORY, BRIAN, SELNESS, SHAUN, DURLEY, RICHARD, DEVADAS, BALEKUDRU, PALMQUIST, KATHERINE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Disclosed is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein L and M are independently selected from -O-, -CH2-, -S-, -N(R)-N(R)-, -C(=O)- and -SO2-, and the remaining substituents are as defined in the specification. The compounds are useful for treating diseases caused by unregulated p38 MAP kinase activity.