Preparation of modafinil comprising reaction with chloroacetamide

Preparation of modafinil comprising reaction with chloroacetamide

Disclosed is a process of preparing modafinil, comprising: (1) reacting benzhydrol with a suitable acid and thiourea to form a S-benzhydrylthiouronium salt; (2) reacting the S-benzhydrylthiouronium salt with a suitable base to form benzhydrylthiol; (3) reacting the benzhydrylthiol with chloroacetami...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LARGEAU, DENIS, ODDON, GILLES
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Disclosed is a process of preparing modafinil, comprising: (1) reacting benzhydrol with a suitable acid and thiourea to form a S-benzhydrylthiouronium salt; (2) reacting the S-benzhydrylthiouronium salt with a suitable base to form benzhydrylthiol; (3) reacting the benzhydrylthiol with chloroacetamide to form 2-(benzhydrylthiyl acetamide; (4) oxidising 2-(benzhydrylthiyl) acetamide with a suitable oxidising agent to form modafinil. Particularly disclosed is step (3) of the above reaction series.