Methods and materials relating to mycoplasma polypeptide preparations having the ability to increase calcium release from porcine ciliated tracheal cells

A substantially pure mycoplasma polypeptide, with a molecular weight between about 30 kDa and 150 kDa, increases calcium release from porcine ciliated tracheal cells. The polypeptide can be used to generate polypeptide fragments that have the ability to block mycoplasma-induced calcium release and c...

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Bibliographische Detailangaben
Hauptverfasser:	ZHOU, EN-MIN, HSU, WALTER H, YOUNG, THERESA F, ROSS, RICHARD F
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A substantially pure mycoplasma polypeptide, with a molecular weight between about 30 kDa and 150 kDa, increases calcium release from porcine ciliated tracheal cells. The polypeptide can be used to generate polypeptide fragments that have the ability to block mycoplasma-induced calcium release and can also be used to generate antibodies that bind to the mycoplasma polypeptide. Also disclosed are methods for identifying inhibitors of mycoplasma-induced calcium released from porcine ciliated tracheal cells.