Inhibitors of cytosolic phospholipase A2

Disclosed are compounds of formula (I), wherein: R is -(CH2)n-A, -(CH2)n-S-A, or -(CH2)n-O-A, and the remaining substituents are defined herein. Also disclosed are intermediate compounds of formula (A). The compounds of formula (I) are used in the manufacture of medicaments for the treatment of infl...

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Hauptverfasser: BEHNKE, MARK LEO, THAKKER, PARESH, MCKEW, JOHN CAEDMON, CHEN, LIHREN, TAM, STEVE YIK-KAI, SUM, FUK-WAH, CLARK, JAMES DONALD, LEE, KATHERINE LIN, HU, BAIHUA
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creator BEHNKE, MARK LEO
THAKKER, PARESH
MCKEW, JOHN CAEDMON
CHEN, LIHREN
TAM, STEVE YIK-KAI
SUM, FUK-WAH
CLARK, JAMES DONALD
LEE, KATHERINE LIN
HU, BAIHUA
description Disclosed are compounds of formula (I), wherein: R is -(CH2)n-A, -(CH2)n-S-A, or -(CH2)n-O-A, and the remaining substituents are defined herein. Also disclosed are intermediate compounds of formula (A). The compounds of formula (I) are used in the manufacture of medicaments for the treatment of inflammation, pain, asthma or arthritic and/or rheumatic disorders in a mammal.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Inhibitors of cytosolic phospholipase A2
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