Inhibitors of cytosolic phospholipase A2

Inhibitors of cytosolic phospholipase A2

Disclosed are compounds of formula (I), wherein: R is -(CH2)n-A, -(CH2)n-S-A, or -(CH2)n-O-A, and the remaining substituents are defined herein. Also disclosed are intermediate compounds of formula (A). The compounds of formula (I) are used in the manufacture of medicaments for the treatment of infl...

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Bibliographische Detailangaben
Hauptverfasser: BEHNKE, MARK LEO, THAKKER, PARESH, MCKEW, JOHN CAEDMON, CHEN, LIHREN, TAM, STEVE YIK-KAI, SUM, FUK-WAH, CLARK, JAMES DONALD, LEE, KATHERINE LIN, HU, BAIHUA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Disclosed are compounds of formula (I), wherein: R is -(CH2)n-A, -(CH2)n-S-A, or -(CH2)n-O-A, and the remaining substituents are defined herein. Also disclosed are intermediate compounds of formula (A). The compounds of formula (I) are used in the manufacture of medicaments for the treatment of inflammation, pain, asthma or arthritic and/or rheumatic disorders in a mammal.