Mutant actinosynnema pretiosum strain with increased maytansinoid production

Mutant actinosynnema pretiosum strain with increased maytansinoid production

Disclosed are mutant bacterial strains of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins in improved yield compared to previous known strains, and capable of growth under varied culture conditions. Further disclosed are me...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CHUNG, JOHNSON, BYNG, GRAHAM S
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:Disclosed are mutant bacterial strains of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins in improved yield compared to previous known strains, and capable of growth under varied culture conditions. Further disclosed are methods of producing maytansinoid ansamitocins by culturing the aforementioned strains in a suitable growth medium.