Aminobenzamide derivatives as glycogen synthase kinase 3beta inhibitors

Disclosed are compounds of formula (I), wherein: R1 is H, aryl, formyl, alkylcarbonyl, alkyl, substituted alkyloxycarbonyl or substituted alkyloxyalkylcarbonyl, R2 is H, alkyl, alkenyl, alkynyl, R20, each optionally substituted, R4a and R4b are independently H or alkyl, and the remaining substituent...

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Hauptverfasser:	BUIJNSTERS, PETER JACOBUS JOHANNES ANTONIUS, FREYEN, EDDY JEAN EDGARD, DE JONGE, MARC RENE, GEERTS, HUGO ALFONS GABRIEL, WILLEMS, MARC, MERCKEN, MARC HUBERT, EMBRECHTS, WERNER CONSTANT JOHAN, LEWI, PAULUS JOANNES, JANSSEN, PAUL ADRIAAN JAN, DAEYAERT, FREDERIK FRANS DESIRE, HEERES, JAN, KOYMANS, LUCIEN MARIA HENRICUS, KUKLA, MICHAEL JOSEPH, LUDOVICI, DONALD WILLIAM, NUYDENS, RONY MARIA
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds of formula (I), wherein: R1 is H, aryl, formyl, alkylcarbonyl, alkyl, substituted alkyloxycarbonyl or substituted alkyloxyalkylcarbonyl, R2 is H, alkyl, alkenyl, alkynyl, R20, each optionally substituted, R4a and R4b are independently H or alkyl, and the remaining substituents are defined herein. The compounds are used in the manufacture of medicaments for the treatment of diseases mediated through GSK3.