HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis

HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis

Disclosed are compounds of formula I, wherein: R1 is optionally substituted phenyl, R2 is optionally substituted alkenyl or alkynyl, R2' is H, X is phenyl, Z is S, SO or SO2, R3, R4, R5, R8 and R8' are H, and R6 and R7 are methyl. The compounds are used in the manufacture of medicaments fo...

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Hauptverfasser: BOYER FREDERICK E, BOLTON, GARY L, HOLLER, TOD P, BARVIAN, MARK R, BURKE, BENJAMIN J, JOSYULA, VARA PRASAD VENKATA NAGENDRA, KUCERA, DAVID J, JEWELL, TANYA M, ALEXANDER, THERESE N, CANON-KOCH, STACIE S, MACHAK, JEFF J
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed are compounds of formula I, wherein: R1 is optionally substituted phenyl, R2 is optionally substituted alkenyl or alkynyl, R2' is H, X is phenyl, Z is S, SO or SO2, R3, R4, R5, R8 and R8' are H, and R6 and R7 are methyl. The compounds are used in the manufacture of medicaments for the treatment of diseases mediated by HIV infection.