Oxazol/ thiazol-derivatives activators of the hPPAR- alpha receptor
Activators of the hPPAR receptor comprise the compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof, wherein: X1 represents O; R1 and R2 are methyl; R3 and R4 independently represent H, halogen, -CH3 and -OCH3; R5 represents H; X2 represents NH; Z is...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | GELLIBERT, FRANCOISE JEANNE |
| description | Activators of the hPPAR receptor comprise the compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof, wherein: X1 represents O; R1 and R2 are methyl; R3 and R4 independently represent H, halogen, -CH3 and -OCH3; R5 represents H; X2 represents NH; Z is N, and Y is S; R6 represents phenyl and is optionally substituted by one or more halogen, CF3, C1-6 straight or branched alkyl (optionally substituted by halogen). Also disclosed is the use of the compound in therapy and a pharmaceutical composition comprising the compound for the manufacture of a medicament for the treatment of an hPPAR alpha disease or condition such as dyslipidemia, syndrome X, heart failure, hypocholesteremia, cardiovascular disease, type II diabetes mellitus, type I diabetes, insulin resistance, hyperlipidemia, obesity, anorexia bulimia and anorexia nervosa. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_NZ529754A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>NZ529754A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_NZ529754A3</originalsourceid><addsrcrecordid>eNrjZHD2r0isys_RVyjJyAQxdFNSizLLEksyy1KLFRKTS0Ds_KJihfw0oIpUhYyAAMcgXYXEnIKMRIWi1OTUAqAsDwNrWmJOcSovlOZmkHNzDXH20E0tyI9PLS5ITE7NSy2J94syNbI0NzVxNCaoAABARzEU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Oxazol/ thiazol-derivatives activators of the hPPAR- alpha receptor</title><source>esp@cenet</source><creator>GELLIBERT, FRANCOISE JEANNE</creator><creatorcontrib>GELLIBERT, FRANCOISE JEANNE</creatorcontrib><description>Activators of the hPPAR receptor comprise the compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof, wherein: X1 represents O; R1 and R2 are methyl; R3 and R4 independently represent H, halogen, -CH3 and -OCH3; R5 represents H; X2 represents NH; Z is N, and Y is S; R6 represents phenyl and is optionally substituted by one or more halogen, CF3, C1-6 straight or branched alkyl (optionally substituted by halogen). Also disclosed is the use of the compound in therapy and a pharmaceutical composition comprising the compound for the manufacture of a medicament for the treatment of an hPPAR alpha disease or condition such as dyslipidemia, syndrome X, heart failure, hypocholesteremia, cardiovascular disease, type II diabetes mellitus, type I diabetes, insulin resistance, hyperlipidemia, obesity, anorexia bulimia and anorexia nervosa.</description><edition>7</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20051223&DB=EPODOC&CC=NZ&NR=529754A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25546,76297</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20051223&DB=EPODOC&CC=NZ&NR=529754A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GELLIBERT, FRANCOISE JEANNE</creatorcontrib><title>Oxazol/ thiazol-derivatives activators of the hPPAR- alpha receptor</title><description>Activators of the hPPAR receptor comprise the compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof, wherein: X1 represents O; R1 and R2 are methyl; R3 and R4 independently represent H, halogen, -CH3 and -OCH3; R5 represents H; X2 represents NH; Z is N, and Y is S; R6 represents phenyl and is optionally substituted by one or more halogen, CF3, C1-6 straight or branched alkyl (optionally substituted by halogen). Also disclosed is the use of the compound in therapy and a pharmaceutical composition comprising the compound for the manufacture of a medicament for the treatment of an hPPAR alpha disease or condition such as dyslipidemia, syndrome X, heart failure, hypocholesteremia, cardiovascular disease, type II diabetes mellitus, type I diabetes, insulin resistance, hyperlipidemia, obesity, anorexia bulimia and anorexia nervosa.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHD2r0isys_RVyjJyAQxdFNSizLLEksyy1KLFRKTS0Ds_KJihfw0oIpUhYyAAMcgXYXEnIKMRIWi1OTUAqAsDwNrWmJOcSovlOZmkHNzDXH20E0tyI9PLS5ITE7NSy2J94syNbI0NzVxNCaoAABARzEU</recordid><startdate>20051223</startdate><enddate>20051223</enddate><creator>GELLIBERT, FRANCOISE JEANNE</creator><scope>EVB</scope></search><sort><creationdate>20051223</creationdate><title>Oxazol/ thiazol-derivatives activators of the hPPAR- alpha receptor</title><author>GELLIBERT, FRANCOISE JEANNE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NZ529754A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2005</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GELLIBERT, FRANCOISE JEANNE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GELLIBERT, FRANCOISE JEANNE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Oxazol/ thiazol-derivatives activators of the hPPAR- alpha receptor</title><date>2005-12-23</date><risdate>2005</risdate><abstract>Activators of the hPPAR receptor comprise the compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof, wherein: X1 represents O; R1 and R2 are methyl; R3 and R4 independently represent H, halogen, -CH3 and -OCH3; R5 represents H; X2 represents NH; Z is N, and Y is S; R6 represents phenyl and is optionally substituted by one or more halogen, CF3, C1-6 straight or branched alkyl (optionally substituted by halogen). Also disclosed is the use of the compound in therapy and a pharmaceutical composition comprising the compound for the manufacture of a medicament for the treatment of an hPPAR alpha disease or condition such as dyslipidemia, syndrome X, heart failure, hypocholesteremia, cardiovascular disease, type II diabetes mellitus, type I diabetes, insulin resistance, hyperlipidemia, obesity, anorexia bulimia and anorexia nervosa.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_NZ529754A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Oxazol/ thiazol-derivatives activators of the hPPAR- alpha receptor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T09%3A34%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=GELLIBERT,%20FRANCOISE%20JEANNE&rft.date=2005-12-23&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ENZ529754A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |