Glycosylated interferon gamma polypeptide variants

An interferon gamma (IFNG) S99T polypeptide variant which has a threonine at position 99 exhibiting IFNG activity and having the amino acid sequence shown in SEQ ID NO:1, or a carboxy (C-) terminally truncated fragment thereof exhibiting IFNG activity. Also described are other variants of the IFNG S...

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Bibliographische Detailangaben
1. Verfasser:	JENSEN, ANNE DAM
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	An interferon gamma (IFNG) S99T polypeptide variant which has a threonine at position 99 exhibiting IFNG activity and having the amino acid sequence shown in SEQ ID NO:1, or a carboxy (C-) terminally truncated fragment thereof exhibiting IFNG activity. Also described are other variants of the IFNG S99T polypeptide, expression vectors and host cells comprising the polypeptide and the use of the polypeptide variant in a pharmaceutical composition to treat interstitial pulmonary diseases.