Inhibition of differentiation of cytotoxic T-cells by P-selectin ligand (PSGL) antagonists

Use of a mimetic which inhibit sLex binding in the manufacture of a medicament for treating ameliorating an autoimmune condition and/or ameliorating an allergic reaction is disclosed, wherein differentiation of an activated T-cell into a cytotoxic lymphocyte in a mammalian subject is inhibited. (62)...

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Bibliographische Detailangaben
Hauptverfasser:	MANJUNATH, NARASIMHASWAMY, HANS VON ANDRIAN, ULRICH
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Use of a mimetic which inhibit sLex binding in the manufacture of a medicament for treating ameliorating an autoimmune condition and/or ameliorating an allergic reaction is disclosed, wherein differentiation of an activated T-cell into a cytotoxic lymphocyte in a mammalian subject is inhibited. (62) Divided Out of 511836