Sulfonamide inhibitors of HIV aspartyl protease

Sulfonamides that are aspartyl protease inhibitors such as HIV aspartyl protease inhibitors are disclosed, wherein specific structural and physicochemical features characterise the class of HIV aspartyl protease inhibitors. The compounds and pharmaceutical compositions of these sulfonamides are part...

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Hauptverfasser: ANDREWS, CLARENCE WEBSTER, LOWEN, GREGORY THOMAS, SHERRILL, RONALD GEORGE, SPALTENSTEIN, ANDREW, FURFINE, ERIC STEVEN, HALE, MICHAEL R
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Sprache:eng
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Zusammenfassung:Sulfonamides that are aspartyl protease inhibitors such as HIV aspartyl protease inhibitors are disclosed, wherein specific structural and physicochemical features characterise the class of HIV aspartyl protease inhibitors. The compounds and pharmaceutical compositions of these sulfonamides are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. Methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity are also disclosed. (62) Divided out of 508855