Novel aggrecanase molecules

The identification of aggrecanase protein molecules capable of cleaving aggrecanase, the nucleotide sequences which encode aggrecanase enzymes and the processes for the production of aggrecanases are disclosed. The composition comprises the aggrecanase enzymes, the antibodies and methods for develop...

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Bibliographische Detailangaben
Hauptverfasser:	RACIE, LISA ANNE, LAVALLIE, EDWARD R, AGOSTINO, MICHAEL JOHN, TWINE, NATALIE CONSTANCE
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The identification of aggrecanase protein molecules capable of cleaving aggrecanase, the nucleotide sequences which encode aggrecanase enzymes and the processes for the production of aggrecanases are disclosed. The composition comprises the aggrecanase enzymes, the antibodies and methods for developing inhibitors of the aggrecanase. The inhibitors and antibodies may be used in the treatment of conditions characterised by degradation of articular cartilage.