2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors

2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors

2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives of formula I is disclosed where: · R1 is selected from the group consisting of hydrogen, halo, and C1-C5 alkyl, said C1-C5alkyl optionally substituted by halo or alkoxy, said alkoxy optionally substituted by one or more halo; · R2 is selected...

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Bibliographische Detailangaben
Hauptverfasser: DURLEY, RICHARD C, SIKORSKI, JAMES, PROMO, MICHELLE A, HANSEN, DONALD, MOORMAN, ALAN E, PITZELE, BARNETT S, AWASTHI, ALOK K, WEBBER, RONALD KEITH
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives of formula I is disclosed where: · R1 is selected from the group consisting of hydrogen, halo, and C1-C5 alkyl, said C1-C5alkyl optionally substituted by halo or alkoxy, said alkoxy optionally substituted by one or more halo; · R2 is selected from the group consisting of hydrogen, halo, and C1-C5 alkyl, said C1-C5 alkyl optionally substituted by halo or alkoxy, said alkoxy optionally substituted by one or more halo; and · R3 is C1-C5 alkyl, said C1-C5 alkyl optionally substituted by halo or alkoxy, said alkoxy optionally substituted by one or more halo. The above-mentioned compounds may be used in therapy as nitric oxide synthase inhibitors.