Phenyl derivatives, processes for their preparation and pharmaceutical compositions containing them

Phenyl derivatives, processes for their preparation and pharmaceutical compositions containing them

Disclosed are compounds of formula (I), wherein: Z1 is a bond, (CH2)q where q is 1 or 2, Z2 is a bond or CH2, provided that Z1 and Z2 are not both simultaneously a bond, Q is an oxygen or sulphur atom, or a group CH2 or NH, R2 is a substituted phenyl, and the remaining substituents are defined herei...

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Hauptverfasser: MUSSIE, TESFALEDET, ERIKSSON, TOMAS, KLINGSTEDT, TOMAS
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed are compounds of formula (I), wherein: Z1 is a bond, (CH2)q where q is 1 or 2, Z2 is a bond or CH2, provided that Z1 and Z2 are not both simultaneously a bond, Q is an oxygen or sulphur atom, or a group CH2 or NH, R2 is a substituted phenyl, and the remaining substituents are defined herein. The compounds are used in the manufacture of medicaments for the treatment of diseases mediated by modulation of chemokine receptor activity, such as inflammatory diseases, chronic obstructive pulmonary disease and multiple sclerosis.