Thienodibenzoazulene compounds as tumor necrosis factor inhibitors

Disclosed are dibenzoazulene derivatives of formula I, wherein: X is CH2, a heteroatom or NR13, R1, R5, R7, R8 and R9 are hydrogen, R2, R3 and R4 are independently H, halogen, alkyl, halomethyl, alkoxy, or alkylthio, R6 is H or halogen, R10 is -CHO, hydroxyalkyls, alkylamine or -(CH2)n-A wherein A i...

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Hauptverfasser:	PESIC, DIJANA, MERCEP, MLADEN, HRVACIC, BOSKA, MESIC, MILAN, ZUPANOVIC, ZELJKO
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are dibenzoazulene derivatives of formula I, wherein: X is CH2, a heteroatom or NR13, R1, R5, R7, R8 and R9 are hydrogen, R2, R3 and R4 are independently H, halogen, alkyl, halomethyl, alkoxy, or alkylthio, R6 is H or halogen, R10 is -CHO, hydroxyalkyls, alkylamine or -(CH2)n-A wherein A is a heterocyclic ring. The derivatives are used in the manufacture of medicaments for the treatment of conditions induced by excessive unregulated production of cytokines or inflammation mediators.