Heterocyclic side chain containing metalloprotease inhibitors

Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to formulae shown; R1, R2, n, A, E, X, G and Z have the meanings described in the...

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Bibliographische Detailangaben
Hauptverfasser:	LAUGHLIN, STEVEN KARL, OHLER, NORMAN EUGENE, NATCHUS, MICHAEL GEORGE, PIKUL, STANISLAW, ALMSTEAD, NEIL GREGORY, DE,BISWANATH
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to formulae shown; R1, R2, n, A, E, X, G and Z have the meanings described in the specification. Pharmaceutical compositions comprising these compounds are also described, and methods of inhibiting metalloprotease-related diseases such as cancer.