Tetracyclic azepinoindole compounds as 5-HT receptor ligands

The present invention provides compounds of formula (I), wherein R1 is OH, nitro, cyano, halo, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy, alkanoyl, alkoxycarbonyl, alkanoyloxy, aryl, heteroaryl, -S(O)mNRaRb, NRcRd,-S(O)mRe or -C(O=)NRaRb; R2 is hydrogen, C1-7alkyl, C1-7alkanoyl, arylcarbonyl,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	ROGERS, BRUCE N, ACKER, BRAD A, NNIS, MICHAEL DALTON, HESTER, JACKSON B, JACOBSEN, E JON, VANDER VELDE, SUSAN L
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention provides compounds of formula (I), wherein R1 is OH, nitro, cyano, halo, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy, alkanoyl, alkoxycarbonyl, alkanoyloxy, aryl, heteroaryl, -S(O)mNRaRb, NRcRd,-S(O)mRe or -C(O=)NRaRb; R2 is hydrogen, C1-7alkyl, C1-7alkanoyl, arylcarbonyl, aryl, (aryl)C1-7alkyl, C1-7alkoxycarbonyl, aryloxycarbonyl, arylsulfonyl, or (aryl)C1-7alkoxycarbonyl; X and Y together are 2, 3 or 4 membered saturated or partially unsaturated chain. These compounds are 5-HT ligands, and are useful for treating diseases wherein modulation of 5-HT activity is desired.