Non-peptide GnRH agents for treating GnRH associated diseases with pyrazole carboxamidine related structures

Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent t...

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Hauptverfasser:	PATHAK, VED P, CHRISTIE, LANCE CHRISTOPHER, PADERES, GENEVIEVE DEGUZMAN, VAZIR, HARESH N, HONG, YUFENG, ANDERSON, MARK BRIAN, LUTHIN, DAVID ROBERT, FAUST, JAMES, LI, HAITAO, TOMPKINS,EILEEN VALENZUELA
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesising the compounds and intermediates useful in their preparation are also described.