Benzenesulfonamide inhibitors of phosphodiesterase-IV for treating inflammation and TNF associated diseases

A method of inhibiting PDE-IV or TNF comprising contacting a cell with a compound of the formula shown. The pharmaceutical composition is suitable for the treatment of inflammatory or autoimmune diseases. Wherein; R1 and R2 represents C1-4alkyl or C3-10cycloalkyl; R3 and R4 independently represents...

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Hauptverfasser:	MENETSKI, JOSEPH PETER, CONNOR, DAVID THOMAS
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	MENETSKI, JOSEPH PETER CONNOR, DAVID THOMAS
description	A method of inhibiting PDE-IV or TNF comprising contacting a cell with a compound of the formula shown. The pharmaceutical composition is suitable for the treatment of inflammatory or autoimmune diseases. Wherein; R1 and R2 represents C1-4alkyl or C3-10cycloalkyl; R3 and R4 independently represents C1-4alkyl, cycloalkyl, C2-4alkylenes having one double bond, (CH2)nCO(CH2)mCH3, (CH2)pCN, (CH2)pCO2Me, or taken together with nitrogen atom to which they are attached, form a 3-to 10-membered ring; n and m are 0-3; p is 1 to 3.
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	Benzenesulfonamide inhibitors of phosphodiesterase-IV for treating inflammation and TNF associated diseases
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