Benzenesulfonamide inhibitors of phosphodiesterase-IV for treating inflammation and TNF associated diseases

A method of inhibiting PDE-IV or TNF comprising contacting a cell with a compound of the formula shown. The pharmaceutical composition is suitable for the treatment of inflammatory or autoimmune diseases. Wherein; R1 and R2 represents C1-4alkyl or C3-10cycloalkyl; R3 and R4 independently represents...

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Bibliographische Detailangaben
Hauptverfasser:	MENETSKI, JOSEPH PETER, CONNOR, DAVID THOMAS
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A method of inhibiting PDE-IV or TNF comprising contacting a cell with a compound of the formula shown. The pharmaceutical composition is suitable for the treatment of inflammatory or autoimmune diseases. Wherein; R1 and R2 represents C1-4alkyl or C3-10cycloalkyl; R3 and R4 independently represents C1-4alkyl, cycloalkyl, C2-4alkylenes having one double bond, (CH2)nCO(CH2)mCH3, (CH2)pCN, (CH2)pCO2Me, or taken together with nitrogen atom to which they are attached, form a 3-to 10-membered ring; n and m are 0-3; p is 1 to 3.