Medicinal formulations comprising biocompatible polymers of the formula -[X-R-C(O)]- for pharmaceutical drug delivery systems
Methods, compounds, and medicinal formulations utilising biocompatible polymers for solubilizing, stabilising and/or providing sustained release of a drug from topical, implantable, and inhalation systems are described. Many of the methods, compounds, and medicinal formulations are particularly suit...
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Zusammenfassung: | Methods, compounds, and medicinal formulations utilising biocompatible polymers for solubilizing, stabilising and/or providing sustained release of a drug from topical, implantable, and inhalation systems are described. Many of the methods, compounds, and medicinal formulations are particularly suitable for oral and/or nasal inhalation and can also be made for delivery via, for example, topical spray-on administration (e.g., buccal, transdermal). The formulations can be solids, semi-solids, or liquids and use polymers of the formula -[X-R1-C(O)]- wherein each R1 is an independently selected organic group that links the -X- group to the carbonyl group, and each X is independently oxygen, sulphur, or catenary nitrogen. Additionally, compositions (e.g., those made with low polydispersity and/or medicinal salt biocompatible polymers) capable of forming stable preformed solid objects, such as dry powders, microspheres, rods, pins, etc., can be made for delivery by injection, implantation or other suitable methods. |
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